- The title is a reference to the Carl Reiner & Mel Brooks comedy sketch The 2000-Year-Old Man[1] as well as the film The 40-Year-Old Virgin.
- Meg acting as a tag remover, looking at the camera and saying, "It's a living" followed by "wah-wah-wah" music is a reference to the birds on The Flintstones.
- Peter encouraging offended Christians who might be watching to mail complaints to the Family Television Council is a jab at the Parents Television Council, a Christian pro-censorship group and one of the show's most vocal critics.
- The closing where Rupert gives Stewie a Joni Mitchell CD and Stewie wonders who the necklace was for, is in reference to a scene in the film Love Actually.
Previous Episode's References /// The 2000-Year-Old Virgin's References \\\ Next Episode's References
| << Season 12 | Family Guy Season 13 | Season 14 >> | |||||||||
| #01 | The Simpsons Guy | #07 | Stewie, Chris & Brian's Excellent Adventure | #13 | Dr. C & The Women | ||||||
| #02 | The Book of Joe | #08 | Our Idiot Brian | #14 | #JOLO | ||||||
| #03 | Baking Bad | #09 | This Little Piggy | #15 | Once Bitten | ||||||
| #04 | Brian the Closer | #10 | Quagmire's Mom | #16 | Roasted Guy | ||||||
| #05 | Turkey Guys | #11 | Encyclopedia Griffin | #17 | Fighting Irish | ||||||
| #06 | The 2000-Year-Old Virgin | #12 | Stewie Is Enceinte | #18 | Take My Wife |
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