The Blues Brothers is a 1980 musical comedy directed by John Landis and starring John Belushi and Dan Aykroyd as "Joliet" Jake and Elwood Blues, characters developed from a musical sketch on the NBC variety series Saturday Night Live. It features musical numbers by R&B and soul singers James Brown, Cab Calloway, Aretha Franklin, Ray Charles, and John Lee Hooker. The film is set in and around Chicago, Illinois, and also features non-musical supporting performances by John Candy, Carrie Fisher, Charles Napier and Henry Gibson.

In "North by North Quahog", Peter Griffin drives through the mall pursued by Mel Gibson’s goons. The song “I Can’t Turn You Loose” also plays.

In "Sibling Rivalry", Stewie’s giving orders at the playground and quotes a flophouse resident in The Blues Brothers, “Did ya get me my Cheez Whiz, boy?” as Elwood Blues throws him his Cheez Whiz.

In Road to Germany", when the German sub crashes into the ocean floor, it is quickly followed a large number of crashing police cars. The DVD extends this scene with John Candy as the parole officer.

In Blue Harvest, the gang tries to act cool to sneak by Imperial Guards. The song "Minnie the Moocher" plays and they all slowly creep by doing a stealthy walk. In the movie, the brothers avoid cops while the song plays.

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