- This is the third episode to have the name Joe in the title following "Believe It or Not, Joe's Walking on Air" and "Joe's Revenge".
- Chris has no dialogue in this episode.
- In a cutaway gag, Gene Shalit's wife is named JoAnne. In reality, he is a widower and his late wife's name was Nancy.
- This is Mike Desilets first solo writing credit.
- Tom Petty and the Heartbreakers' "Runnin' Down A Dream" plays when Brian experiences a runner's high.
- "Sirius" by The Alan Parsons Project plays during the laser introduction of The Hopeful Squirrel 2.
- A week after this episode aired, Bono revealed the real reason he wore sunglasses was because he was going blind from glaucoma.[1]
- Al Harrington refers to his company as Al Harrington's Wacky Waving Inflatable Arm-Flailing Tube Men Warehouse and Emporium in this episode whereas in other episodes, the words "Warehouse" and "Emporium" should be swapped.
Previous Episode's Notes/Trivia /// The Book of Joe's Notes/Trivia \\\ Next Episode's Notes/Trivia
| << Season 12 | Family Guy Season 13 | Season 14 >> | |||||||||
| #01 | The Simpsons Guy | #07 | Stewie, Chris & Brian's Excellent Adventure | #13 | Dr. C & The Women | ||||||
| #02 | The Book of Joe | #08 | Our Idiot Brian | #14 | #JOLO | ||||||
| #03 | Baking Bad | #09 | This Little Piggy | #15 | Once Bitten | ||||||
| #04 | Brian the Closer | #10 | Quagmire's Mom | #16 | Roasted Guy | ||||||
| #05 | Turkey Guys | #11 | Encyclopedia Griffin | #17 | Fighting Irish | ||||||
| #06 | The 2000-Year-Old Virgin | #12 | Stewie Is Enceinte | #18 | Take My Wife |
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