- The title is a reference to the film Monty Python's Life of Brian.
- When Brian discovers that he has a son, Stewie, with much anticipation, yells, "Jerry! Jerry! Jerry!" in reference to The Jerry Springer Show.
- Sonny, the Cuckoo Bird from the Cocoa Puffs advertising campaign is subjected to a psychological evaluation, where the tester presents to him a bowl of the cereal to test his reaction. This is a reference to his famous motto "cuckoo for Cocoa Puffs!" The bird, however, refuses to take the bait.
- The Pink Panther's lungs being filled with Owens-Corning fiberglass insulation is a reference to the Owens-Corning commercials that featured the Pink Panther.[1]
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