- This episode's title is a reference to the 1983 comedy starring Steve Martin & Kathleen Turner, The Man With Two Brains.
- When Peter and Brian are talking in the kitchen, there is a reference to Back to the Future when Peter is wearing Doc Brown's mind reading device and shouts, "It means that this damn thing doesn't work at all!"
- Peter says he is The Greatest American Hero which was a superhero drama-comedy that ran from 1981-1983. Peter then sings the show's theme song "Believe It or Not", which is also the title of a previous episode called "Believe It or Not, Joe's Walking on Air".
- When New Brian walks into the kitchen just before the "I Like Farts" song, Peter says, "Oh, you have a guitar!" just like the mother of the sick girl does in the film Airplane!.
Previous Episode's References /// The Man with Two Brians's References \\\ Next Episode's References
| << Season 6 | Family Guy Season 7 | Season 8 >> | ||||||
| #01 | Love, Blactually | #07 | Ocean's Three and a Half | #13 | Stew-Roids | |||
| #02 | I Dream of Jesus | #08 | Family Gay | #14 | We Love You, Conrad | |||
| #03 | Road to Germany | #09 | The Juice Is Loose | #15 | Three Kings | |||
| #04 | Baby Not On Board | #10 | FOX-y Lady | #16 | Peter's Progress | |||
| #05 | The Man with Two Brians | #11 | Not All Dogs Go To Heaven | |||||
| #06 | Tales of a Third Grade Nothing | #12 | 420 | |||||