Thelma & Louise is a 1991 film co-produced and directed by Ridley Scott and written by Callie Khouri, the film's plot revolves around Thelma and Louise's escape from their troubled and caged lives. It stars Geena Davis as Thelma and Susan Sarandon as Louise, and co-stars Harvey Keitel as a sympathetic detective trying to trace them as they go on the run after killing a rapist. Michael Madsen plays the role of Louise's boyfriend. Brad Pitt plays a robber out on parole.
During "Road to Rhode Island"'s musical number of the same name, Brian compared himself and Stewie to Thelma & Louise.
In "Livin' on a Prayer", Lois admits kidnapping Scotty Jennings gave her a rush like Thelma & Louise. Peter isn't sure about that given the ending to the film. The ensuing cutaway of the film's climax when they drive into the Grand Canyon is interrupted when they start to have second thought and stop the car, only to have Peter push them in proclaiming them to be terrible women.