Thomas Jefferson (April 13, 1743 – July 4, 1826) was the third President of the United States (1801–1809), the principal author of the Declaration of Independence (1776), and one of the most influential Founding Fathers.
In "The Story on Page One", he decides to allow the children he fathered with his African American slaves into his family photo.
His face is also seen on Mount Rushmore in "North by North Quahog" and in "Baking Bad".
Jefferson tries to get congress to approve the Louisiana Purchase in "Stewie, Chris & Brian's Excellent Adventure".
Brian pursues a scam in "The New Adventures of Old Tom", comparing it to Theodore Roosevelt being on Mount Rushmore without having participated in a major event compared to the others.